Kushi (Kushinada) is a beautiful rice-growing sake brewer in Kamiki Village and the love interest of Susano. She is gentle, patient, and good natured but strong willed, able to tolerate Susano's antics and is not angered when he drinks all her sake or leaves her with a heavy load to carry. Unlike most others she has a strong faith in the gods and was one of the few people able to see Ōkami Amaterasu's markings from the beginning after her mill wheel was fixed.
During Orochi’s right of sacrifice Kushi is chosen as the next maiden. She willing goes to Orochi’s cave telling the villagers hide and takes along a jug of her Thunder Brew since Susano drank all the 8 Purification Sake that would typically have been used. After being saved by Susano the two express their love for one another and spend the Kamiki Festival in the Cave of Nagi. In Ōkamiden she has an adopted son named Kuni and is later revealed to be pregnant with Susano’s child.
Kushi is based on the fictional character Kushinada-hime who was intended as a sacrifice to Yamata-no-Orochi but was saved by Susano-o who turned her into a comb which he hid in his own hair. Because of this tale Kushi's hairstyle in the game is designed to look like a traditional Japanese comb.