"Sailing is like sex. If you do it wrong, you will get sick... but do it right, and there's no feeling in the world like it." -Isabela
"A warehouse? I don't like being led around. Unless leashes are involved. And they're not."' -Isabela
"I like big Boats, I cannot lie." -Isabela
"You see, sweetness, men are only good for one thing. Women are good for six." -Isabela
Ironically her name means "devoted to God" in Hebrew, even though she has no respect for religions.
When encountering the Desire Demon in the side quest Night Terrors, upon betraying Hawke, Isabela will say "I like big boats, I cannot lie," a reference to the song Baby Got Back by Sir Mix-A-Lot.
In a party banter with Aveline, she'll make several sexually-based references to Origins, including "Shank your Jory", "Grey your Warden", "Master your Taint", and "Arl your Eamon".
If you take Isabela into the Deep Roads she may comment nervously on how she "really doesn't like tight spaces", implying that she is claustrophobic.
The Line "Step 1: We find Velasco. Step 2: Something exciting happens. Step 3: Profit" is a reference to the Underpants Gnomes in the TV show South Park, whose business plan was "Phase 1: Collect underpants. Phase 2: ? Phase 3: Profit."
Upon meeting King Alistair in Viscount's Keep, Alistair will say that Isabela looks different, to which Isabela will respond "Don't we all." This is probably an in-game joke referring to the changes in character appearance between the games. If imported from Origins where Alistair is exiled or selecting the "No Compromise" backstory, Alistair will be found intoxicated in The Hanged Man, where Isabela and Alistair will not recognize each other. She will say he's been ranting about being the "Prince of Ferelden" all day and he will say she sounds like Morrigan.
"Fools Rush In" quest title may be a reference to the movie "Fools Rush In", in which Salma Hayek plays a character named Isabel.