Rameses is the tertiary antagonist in Uncharted 3: Drake's Deception. He is voiced by Sayed Badreya. Shortly after Drake is drugged and passes out, he is taken to a shipyard where he is tied to a chair. Rameses demands Drake to tell him where Atlantis of the Sands is located. When Drake tells Rameses that he honestly did not know, Rameses walks out and threatens to interrogate Sully. After Drake manages to break free and defeat all of the guards, he climbs onto Rameses' cruise ship. From there he finds a decoy of Sully and realizes that he was never there to begin with. Rameses tells him that he lied - he is after all a pirate. Drake then shoots him, critically wounding him. After Drake makes his way into the ball room (the ship turned onto its side at this point because it was sinking), Rameses shoots the glass window and causes the rest of the ship to flood, dying in the process. Drake however survives by drifting to shore on a piece of flotsam.
Source: Wikipedia, "List of Uncharted characters", available under the CC-BY-SA License.