Atelier Ayesha stars a lonely girl who runs an alchemy studio. After her grandfather died, Ayesha’s younger sister Nio disappeared when she was gathering herbs. One day, Ayesha sees Nio walking through ruins which starts her journey. Overcoming sadness is one of the game’s themes and players will see Ayesha grow as she writes diary entries.
The goal of this game is to reunite Ayesha Altugle with her younger sister Nio who went missing while gathering herbs. Atelier Ayesha takes place in a new world separate from the Arland saga where the art of alchemy is out of style. Most people forgot about it and Ayesha lives in an ever changing world.
Source: Wikipedia, "Atelier Ayesha: The Alchemist of Twilight Land", available under the CC-BY-SA License.