In Titanfall 2, players control Titans, mecha-style exoskeletons and their pilots, who are agile and equipped with a variety of skills ranging from wall-running to cloaking. Set in a science fiction universe, the single-player campaign follows the story of Jack Cooper, a rifleman from the Frontier Militia, who bonds with his mentor's Titan BT-7274 after his mentor is killed in action. Together, they embark on a quest to stop the Interstellar Manufacturing Corporation (IMC) from launching a superweapon that is threatening to destroy the Militia planet Harmony. The game's two-year development cycle began in mid-2014. The decision to add a single-player campaign to the game came about because the team wanted to expand the game's player base. They came up with different ideas and prototypes, and integrated them to form a single coherent campaign. The team also overhauled the progression system and made subtle changes to the multiplayer to make the gameplay more fair.
Similar to its predecessor, Titanfall 2 is a first-person shooter where players can control both a pilot and their Titans—mecha-style robots that stand roughly seven to ten meters tall. The pilot has a large variety of equipment that enhance their abilities during combat. All pilots have a jump kit which assists with parkour, double-jumping, and wall-running. Pilots have more specific abilities unique to each 'class' which augments their offensive and defensive ability, such as a grappling hook for enhanced mobility, or a holographic visual cloaking device. Pilots use their jump kits to run on walls, movements which can be chained together to travel between locations quickly. The game introduces several new gameplay mechanics. These include: a movement system that allows players to slide on the ground, the pulse blade (which is a throwing knife that reveals the location of any nearby enemy), the holo-pilot, (a holographic pilot that mimics players' action to confuse enemies), and a grappling hook, which can be used to slingshot players to a building or reel in an enemy it attaches to. The Pilots have a large arsenal of gadgets and weapons, such as shotguns, submachine guns, pistols, and grenades to fight their enemies.