In Doom VFR you play a scientist who was killed during the original invasion of Mars. They are resurrected — in a sense — with their consciousness implanted in an artificial intelligence which has the ability to take control of any robot on the station.
This means that rather than inhabiting the same body for the entirety of the game like the original DOOM, you'll be jumping into a variety of different robots littered through the station.
Instead of just mowing through enemies relentlessly, there is a bit of a different pace with Doom VFR. You'll still be thrashing enemies as you clean up the station, and additionally, you'll also be working to put the station back into some semblance of order.