Anachronox

From Wikipedia:
Anachronox (pronounced /əˈnækrənɒks/) is a 3-D, third person computer role-playing game produced by Tom Hall and the Ion Storm games studio and released in 2001.

Gameplay was notably influenced by console RPGs such as Chrono Trigger, one of Tom Hall's favorite video games[1], although character statistics and item collection have been simplified and the emphasis is on exploration and story-telling rather than RPG-style character building. The player plays the part of Sylvester "Sly Boots" Bucelli, a down-and-out detective in the slums of an alien world called Anachronox. This world sits inside a giant, hollow sphere called Sender One, which is the center of the galaxy's network of space-lanes. Recruited against his will to investigate a mystery concerning the very nature of the universe, Sly travels throughout the galaxy, meeting many characters along the way, some of whom can join the player's party.