Desert Demolition Starring Road Runner and Wile E. Coyote is a video game for the Sega Mega Drive/Genesis. Wile E. Coyote and Road Runner are having a competition to see who will win the Acme prize for best customers of the year.
Sometimes Wile E. Coyote and Road Runner share the same levels when playing as them. Other times they don't. Each stage is split up into 2 parts. There are also bonus levels after each mission if the player gets 125 stamps. Looney Tunes stars make a cameo appearance in these bonus stages. Both characters can jump and run faster than normal by getting certain boosts.
Source: Wikipedia, "Desert Demolition", available under the CC-BY-SA License.