The arcade game is a version with simultaneous 2 player support. In addition, there are other changes:
* Life gauges are shown with visible bars, where Duke and bosses all have 11 bars or life.
* In English version, it is no longer possible to refill life bar by adding credits after completing Mission 1.
* With the exception of Mission 9, there are more enemies on screen, including boss battles.
* In high score entry screen, a countdown timer is shown.
Source: Wikipedia, "Dynamite Duke", available under the CC-BY-SA License.