Buster Buddies is the third game in the Buster Bros./Pang series. The game plays much the same as previous entries in the series. Players must eliminate numerous bubbles that appear on screen by using their vertical-shooting weapons. As bubbles are popped, they split into a group of smaller bubbles. Buster Buddies adds more characters with unique abilities, more weapons, more obstacles, and new enemies. This entry features a art heist theme, therefore many famous art paintings make up the backgrounds in the game.