Super Bust-a-Move 2 is a puzzle game in the Puzzle Bobble series. Like previous games, players need to clear the screen of bubbles before they reach the bottom of the screen. Bubbles are removed by creating sets of 3 or more like-coloured bubbles using the launcher.
There are two main game modes: classic and duel. Classic mode has players attempt a series of challenging bubble arrangements solo, while duel mode pits them against either a CPU or human opponent in head-to-head competition. Super Bust-a-Move 2 features a number of special bubbles that perform differently than normal. Some blow up all the bubbles around them, while others paint existing bubbles new colours.