A medical officer employed by the Concordance Extraction Corporation, Nicole Brennan is the girlfriend of Dead Space protagonist Isaac Clarke. Offered a position on the mining vessel USG Ishimura, Nicole at first was hesitant, but Isaac convinced her to take the job.
Her last communication to Isaac indicated that she was grateful to him for making her accept the posting and was looking forward to the rest of her career. Then, all contact was lost with the Ishimura. Nicole's status was unknown.