Madame Musette first appears when Senel Coolidge was locked in the jail cell in Will Raynard's basement. Musette orders the release of Senel after seeing with his desire to save Shirley Fennes. She orders Will to go with Senel to the Misty Mountains and also gives him the job to find Chloe Valens while outside. Before leaving the city, Musette tells Senel to bring Shirley to house for tea. After the events in the Oresoren Village, Musette is in charge of taking care of Harriet Campbell while her father works to save the world.