More than seventeen years before the start of the story, Kvar developed the Angelus Project, which was to find a host that could actually produce a Cruxis Crystal within the body. At one point, or at the start, a human named Anna became one of the hosts, and she was one of the few that survived successfully. Some point between this and seventeen years before the storyline, Kratos Aurion met Anna on the surface, and at some point freed her from the Human Ranch. Because she was a successful host for the Angelus Project, Kvar hunted them everywhere around the world. Eventually, he and the humans met outside the Iselia Human Ranch, and he removed Anna's Exsphere. As the Exsphere was without a Key Crest, her mana became out of control, and she attacked both Kratos and their son, Lloyd Irving. In the end, they managed to get the Exsphere away from Kvar, but Kratos was forced to mortally wound Anna. Seeing an opportunity while Kratos was in shock, Kvar attacked, which sent Anna, Lloyd and their pet, Noishe, down the cliff. Kvar somehow got away while Kratos fought the last Desians and headed down to look after his family, but the Grand Cardinal himself never found the Exsphere and most likely returned to the Asgard Human Ranch, having given up on the Angelus Project for the moment.